Sunday, January 20, 2013

Fiery Orioles manager Earl Weaver dead at 82

FILE - In this July 13, 1974 file photo, Baltimore Orioles manager Earl Weaver literally "flips his lid" as he protests a call by home plate umpire Marty Springstead during a baseball game against the Chicago White Sox in Chicago. Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles, has died, the team announced Saturday, Jan. 19, 2013. He was 82. (AP Photo/File)

FILE - In this July 13, 1974 file photo, Baltimore Orioles manager Earl Weaver literally "flips his lid" as he protests a call by home plate umpire Marty Springstead during a baseball game against the Chicago White Sox in Chicago. Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles, has died, the team announced Saturday, Jan. 19, 2013. He was 82. (AP Photo/File)

FILE - In this Saturday, June 26, 2010 file photo, former Baltimore Orioles manager Earl Weaver (4) waves to the crowd after taking the lineup card out before the start of a baseball game between the Orioles and Washington Nationals, in Baltimore, as members of the Orioles' 1970 team were honored before the start of the game. At right is interim manager Juan Samuel (11). Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles, has died, the team announced Saturday, Jan. 19, 2013. He was 82. (AP Photo/Rob Carr, File)

FILE - In this Friday, June 13, 2008 file photo, former Baltimore Orioles manager Earl Weaver waves to the crowd during a celebration in honor of the 1979 Orioles American League pennant winners before the baseball game between the Baltimore Orioles and Pittsburgh Pirates in Baltimore. Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles, has died, the team announced Saturday, Jan. 19, 2013. He was 82. (AP Photo/Gail Burton, File)

FILE - In this Wednesday, Oct. 11, 1979 file photo, manager Earl Weaver speaks with newsmen outside the Baltimore Orioles' dugout just before the second game of World Series against Pittsburgh Pirates, in Baltimore. Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles, has died, the team announced Saturday, Jan. 19, 2013. He was 82. (AP Photo/File)

FILE - In this Oct. 6, 1969 file photo, Baltimore Orioles manager Earl Weaver, right, and outfielder Frank Robinson celebrate in the dressing room following their team's 11-2 win over the Minnesota Twins for the American League championship, in Minneapolis. Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles, has died, the team announced Saturday, Jan. 19, 2013. He was 82. (AP Photo/File)

BALTIMORE (AP) ? Earl Weaver, the fiery Hall of Fame manager who won 1,480 games with the Baltimore Orioles seemingly was engaged in nearly as many arguments with umpires, has died. He was 82.

Dick Gordon, Weaver's marketing agent, said Saturday that Weaver died while on a Caribbean cruise sponsored by the Orioles. Gordon said Weaver's wife told him that Weaver went back to his cabin after dinner and began choking between 10:30 and 11 Friday night. Gordon said a cause of death has not been determined.

The Duke of Earl, as he was affectionately known in Baltimore, took the Orioles into the World Series four times over 17 seasons but won only one title, in 1970. His .583 winning percentage ranks fifth among managers who served 10 or more seasons in the 20th century.

"Earl Weaver stands alone as the greatest manager in the history of the Orioles organization and one of the greatest in the history of baseball," Orioles owner Peter Angelos said. "This is a sad day for everyone who knew him and for all Orioles fans. Earl made his passion for the Orioles known both on and off the field. On behalf of the Orioles, I extend my condolences to his wife, Marianna, and to his family."

Weaver was a salty-tongued manager who preferred to wait for a three-run homer rather than manufacture a run with a stolen base or a bunt. While some baseball purists argued that strategy, no one could dispute the results.

"He was an intense competitor and smart as a whip when it comes to figuring out ways to beat you," said Davey Johnson, who played under Weaver in the minor leagues and with the Orioles from 1965 to 1972.

Weaver had a reputation as a winner, but umpires knew him as a hothead. Weaver would often turn his hat backward and yell directly into an umpire's face to argue a call or a rule, and after the inevitable ejection he would more often than not kick dirt on home plate or on the umpire's shoes.

He was ejected 91 times, including once in both games of a doubleheader.

Asked once if his reputation might have harmed his chances to gain entry into the Hall of Fame, Weaver admitted, "It probably hurt me."

Those 91 ejections were overshadowed by his five 100-win seasons, six AL East titles and four pennants. Weaver was inducted into the Hall in 1996, 10 years after he managed his final game with Baltimore at the end of an ill-advised comeback.

In 1985, the Orioles' owner at the time, Edward B. Williams, coaxed Weaver away from golf to take over a struggling squad. Weaver donned his uniform No. 4, which had already been retired by the team, and tried to breathe some life into the listless Orioles.

Baltimore went 53-52 over the last half of the 1985 season, but finished seventh in 1986 with a 73-89 record. It was Weaver's only losing season as a major-league manager, and he retired for good after that.

"If I hadn't come back," Weaver said after his final game, "I would be home thinking what it would have been like to manage again. I found out it's work."

Weaver finished with a 1,480-1,060 record. He won Manager of the Year three times.

"I had a successful career, not necessarily a Hall of Fame career, but a successful one," he said.

Weaver came to the Orioles as a first base coach in 1968, took over as manager on July 11 and went on to become the winningest manager in the history of the franchise.

"Earl was such a big part of Orioles baseball and personally he was a very important part of my life and career and a great friend to our family," Hall of Fame shortstop Cal Ripken said. "His passion for the game and the fire with which he managed will always be remembered by baseball fans everywhere and certainly by all of us who had the great opportunity to play for him. Earl will be missed but he can't and won't be forgotten."

He knew almost everything about the game. He was also a great judge of human character, and that's one of the main reasons why he was loved by a vast majority of his players even though he often rode them mercilessly from spring training into October.

"His bark was worse than his bite, but you had to know him and kind of grow up with him, and then you loved him like a father," Johnson said. "He was a used-car salesman in the minor leagues during the offseason, so he learned a lot of ways to sell you on just about anything."

Pat Dobson, who pitched two seasons under Weaver, said, "Certainly, the years I played for him were the two most enjoyable years I've had."

During games Weaver smoked cigarettes in the tunnel leading to the dugout and he never kicked the habit. He suffered a mild heart attack in August 1998, and the Orioles' manager at the time, Ray Miller, wondered aloud how his mentor was holding up.

"I wouldn't want to talk to him if he hasn't had a cigarette in 10 days," Miller joked. "They've probably got him tied to a chair."

Weaver was a brilliant manager, but he never made it to the majors as a player. He finally quit after spending 13 years as a second baseman in the St. Louis organization.

"He talked about how he could drive in 100 runs a year, score 100 runs and never make an error," Johnson said. "He said he never got to the big leagues because the Cardinals had too many good players in front of him."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-19-Obit-Earl%20Weaver/id-037f46874b3e4cbe9511042a07fba7fe

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Getting Into Home Business Network Marketing

Posted by James K. Watts on Jan 20, 2013 in Internet Marketing |




There?s two sides to the network marketing coin (and I assure you it is nothing like Harvey Dent?s coin): one is for the IBOs who are enjoying positive results within their MLM business efforts and the other is for those looking into home business network marketing industry as a means of acquiring a second income source. Either way, each side are quite promising and you are thinking about entering into a world of business that is much more interesting and fascinating than considering exactly the same office day in and day out. It?s quite possible that you?ve developed worn out of the malaise surrounding your cubicle and it?s time you had been confronted with some new faces and merchandise by way of a new endeavor in a home-based business according to multi-level marketing.

If you are an IBO, you?re on the side that?s distributing a very popular network marketing product. By your success, you represent whether your franchise is the kind of company into which new prospects would like to try investing their time and expense. You may have a downline, small or big, also it attracts income opportunity seekers who wants to transition from doing work for another person to working for themselves.

Whenever they get to know you through your downline, you?d like them to find out that you?re a reliable business and you and your group are adhering to the highest standards of business integrity and customer satisfaction.

The other side of the coin is where you find yourself if you are searching for a network marketing business opportunity. On this side you?re responsible for making the correct decision by what kind of MLM business you wish to join. You have to be thinking about the product you need to distribute as if you don?t want it, why would anybody else? You also want to make an informed choice. Therefore, the different options are a bit of time looking up the company online and discovering whether or not it?s a high network marketing business or maybe it?s a lesser-known effort. The more popular it is, the greater your chances are to acquire prospects faster than if no one includes a clue what your merchandise is.

What side with the coin are you betting on? Either way, there doesn?t appear to be a losing chance at all.

Want to uncover the secret of a successful home business network marketing? Find out more by visiting our website. Read more here.

Tags: Internet Marketing

Source: http://www.candam-marketing.com/WP/12940/getting-into-home-business-network-marketing-17/

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Saturday, January 19, 2013

Verizon Galaxy Note 2 getting an update

Verizon Galaxy Note 2

A quick heads up for those of you who own the Verizon Galaxy Home Button, erm, Samsung Galaxy Note 2 -- a software update is currently coming down the pike. We don't know exactly what's in version LL4 (Verizon's usually excellent upgrade info pages are currently failing us), but it's looking like the Exynos exploit is targeted, and that'd make sense, seeing as how other Samsung devices have been updated for the same thing this week.

Update: OK. The changelog is as follows:

  • Android Security Patch added for additional security.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/tj82bRx4CxU/story01.htm

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Umbrella company Tarpon comment on MSC report ...

FOLLOWING a Freedom of Information, it is being reported that the government is clamping down on tax avoidance arrangements through the use of Managed Service Companies (MSCs) legislation.

Says the report, legislation enables the government to recover tax and National Insurance contributions, and has caused investigations to treble in a short period of time. The news will no doubt be of interest to those working within both employment and financial industries, including UK umbrella companies such as Tarpon UK Ltd.

The company which submitted the Freedom of information requests to HM Revenue and Customs (HMRC)? was recruitment law specialist, Lawspeed. It says that the number of MSC tax avoidance arrangement enquiries had risen from 216 to 860, in the space of seven months.

Lawspeed make it clear that since there has been 142 debt transfer notices issued since April 2011, recruitment supply companies that work with service providers should be very cautious.

The MSCs legislation defines Managed Service Companies as any contractor company that pays its worker more than employed levels of income. If HMRC discovers recruiters using companies that chose to avoid tax and National Insurance, this may result in the outstanding tax and National Insurance debt being transferred to them.

A spokesperson from leading UK umbrella company,?Tarpon, commented on the recent discovery:

?Although the number of investigations has risen dramatically, it?s vital that freelancers who are umbrella company employees do not panic. This news will only affect those who continue to avoid paying tax.

?Tarpon are proud to be 100 per cent compliant to all tax legislation, which ensures safety not only to contractors and freelancers, but also clients and agencies.

?Because there are numerous laws and regulations that must be followed when freelancing and contracting in the UK, we believe that it is up to umbrella companies to provide a genuine employment solution that helps create peace of mind for all employees.?

About Tarpon

Tarpon are an umbrella company specialising in contractor tax efficiency, enabling contractors to maximise their income and streamline their admin. Tarpon also provide contractors and agencies with professional advice surrounding potential employment law and tax challenges, including IR35 and AWR.

Discover what your take home pay will be with Tarpon by using our online umbrella company calculator. Or speak to one of our experts, by calling 0800 434 6402.

Contact:
Tarpon UK Ltd,
Unit 12,
Tivoli House,
Wigmore Park Centre,
Luton,
LU2 9XG,
tel: 0800 434 6402

Website: www.tarpon-uk.com

Contact: Darren Paterson

Email: darren@queryclick.com
Website: http://uk.queryclick.com/

Source: http://www.allmediascotland.com/media-releases/44919/umbrella-company-tarpon-comment-on-the-recent-announcement-that-msc-investigations-have-risen-significantly/

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Algerian assault ends crisis, 19 hostages dead

CAPTION CORRECTION, CORRECTS TO THE CITY OF AMENAS, ALGERIA, NOT THE AMENAS GAS FIELD, WHICH IS 45 KM FROM THE CITY AND NOT VISIBLE IN THIS IMAGE - This Oct. 8, 2012 satellite image provided by DigitalGlobe shows the city of Amenas, Algeria. At the Amenas Gas Field, 45 km from the city and not shown in this image, Algerian special forces launched a rescue operation Thursday and freed foreign hostages held by al-Qaida-linked militants, but estimates for the number of dead varied wildly from four to dozens. (AP Photo/DigitalGlobe)

CAPTION CORRECTION, CORRECTS TO THE CITY OF AMENAS, ALGERIA, NOT THE AMENAS GAS FIELD, WHICH IS 45 KM FROM THE CITY AND NOT VISIBLE IN THIS IMAGE - This Oct. 8, 2012 satellite image provided by DigitalGlobe shows the city of Amenas, Algeria. At the Amenas Gas Field, 45 km from the city and not shown in this image, Algerian special forces launched a rescue operation Thursday and freed foreign hostages held by al-Qaida-linked militants, but estimates for the number of dead varied wildly from four to dozens. (AP Photo/DigitalGlobe)

Map locates Ain Amenas, Algeria where hostages were taken

Unidentified rescued hostages pose for the media in Ain Amenas, Algeria, in this image taken from television Friday Jan. 18, 2013. Algeria?s state news service says nearly 100 out of 132 foreign hostages have been freed from a gas plant where Islamist militants had held them captive for three days. The APS news agency report was an unexpected indication of both more hostages than had previously been reported and a potentially breakthrough development in what has been a bloody siege. (AP Photo/Canal Algerie via Associated Press TV)

An unidentified rescued hostage receives treatment in a hospital in Ain Amenas, Algeria, in this image taken from television Friday Jan. 18, 2013. Algeria?s state news service says nearly 100 out of 132 foreign hostages have been freed from a gas plant where Islamist militants had held them captive for three days. The APS news agency report was an unexpected indication of both more hostages than had previously been reported and a potentially breakthrough development in what has been a bloody siege. (AP Photo/Canal Algerie via Associated Press TV)

Roadblocks prevent the access of the Tigentourine gas plant where hostages have been kidnapped by islamic militants, Friday, Jan. 18, 2013. The hostage crisis in the remote desert of Algeria is not over, Britain said Friday, after an Algerian raid on the gas plant to wipe out Islamist militants and free their captives from at least 10 countries unleashed bloody chaos. (AP Photo/Anis Belghoul)

(AP) ? Algerian special forces stormed a natural gas complex in the middle of the Sahara desert on Saturday in a "final assault" that ended a four-day-old hostage crisis, according to the state news agency and two foreign governments. At least 19 hostages and 29 Islamist militants have been killed.

The report, quoting a security source, didn't say whether any hostages or militants remained alive, and it didn't give the nationalities of the dead.

It said the army was forced to intervene after a fire broke out in the plant and said the militants killed the hostages. It wasn't immediately possible to verify who killed the captives.

Seven hostages and 11 militants were killed in Saturday's operation, adding to the previous tally of 12 captives and 18 kidnappers.

The Ain Amenas plant is jointly run by BP, Norway's Statoil and Algeria's state-owned oil company. The governments of Norway and Britain said they received confirmation the siege was over.

The entire refinery was mined with explosives and set to blow up, the Algerian state oil company Sonatrach said in a statement, adding that the process of clearing the explosives had begun. The Algerian media reported that the militants had planned to blow up the complex.

The siege transfixed the world after radical Islamists linked to al-Qaida stormed the complex, which contained hundreds of plant workers from all over the world.

Algeria's response to the crisis was typical of the country's history in confronting terrorists ? military action over negotiation ? and caused an international outcry from countries worried about their citizens. Algerian military forces twice assaulted the areas where the hostages were being held with minimal apparent negotiation ? first on Thursday and then on Saturday.

The latest deaths bring the official Algerian tally of dead to 19 hostages and 29 militants, although reports on the number of dead, injured and freed have been contradictory throughout the crisis. Militants originally said they had seized 41 foreign hostages.

The al-Qaida-linked militants attacked the plant Wednesday morning. They crept across the border from Libya, 60 miles (100 kilometers) away, and fell on a pair of buses taking foreign workers to the airport. The buses' military escort drove off the attackers in a blaze of gunfire that sent bullets zinging over the heads of crouching workers. A Briton and an Algerian ? probably a security guard ? were killed.

Frustrated, the militants turned to the vast gas complex, divided between the workers' living quarters and the refinery itself, and seized hostages, the Algerian government said. The gas flowing to the site was cut off.

On Thursday, Algerian helicopters opened fire on a convoy carrying both kidnappers and their hostages, resulting in many deaths, according to witnesses.

In their final communications, the militants said they were holding seven hostages: three Belgian, two Americans, a Japanese and a Briton. They had threatened to kill them if the Algerian army attacked.

Algerian authorities estimated that about 30 militants occupied the Ain Amenas site Wednesday and with 18 already reported dead, it appeared Saturday that the hostage crisis was finally over.

The standoff has put the spotlight on al-Qaida-linked groups that roam remote areas of the Sahara, threatening vital infrastructure and energy interests. The militants initially said their operation was intended to stop a French attack on Islamist militants in neighboring Mali ? though they later said it was two months in the planning, long before the French intervention.

The accounts of hostages who escaped the complex highlight the cavalier attitude toward their lives taken by both kidnappers and the military.

Ruben Andrada, 49, a Filipino civil engineer who works as one of the project management staff for the Japanese company JGC Corp., described how Algerian helicopter gunships had earlier opened fire on vehicles carrying hostages and the gunmen who used them as shields.

On Thursday, about 35 hostages guarded by 15 militants were loaded into seven SUVs in a convoy to move them from the housing complex to the refinery, Andrada said. The militants placed "an explosive cord" around their necks and were told it would detonate if they tried to run away, he said.

"When we left the compound, there was shooting all around," Andrada said, describing the helicopters' attack. "I closed my eyes. We were going around in the desert. To me, I left it all to fate."

Andrada said when the vehicle he was in overturned, some of the passengers were able to escape. He sustained cuts and bruises and was grazed by a bullet on his right elbow. He later saw the blasted remains of other vehicles, and the severed leg of one of the gunmen.

The site of the gas plant spreads out over several hectares (acres) and includes a housing complex and the processing site, about a mile apart, making it especially complicated for the Algerians to secure the site and likely contributed to the lengthy standoff.

"It's a big and complex site. It's a huge place with a lot of people there and a lot of hiding places for hostages and terrorists," said Col. Richard Kemp, a retired commander of British forces who had dealt with hostage rescues in Iraq and Afghanistan. "These are experienced terrorists holding the hostages."

Casualty figures varied widely. The Algerian government now says 19 hostages and 29 militants have died since Thursday. Before the final assault, the militants claimed through the Mauritanian website ANI that the helicopter attack alone killed 35 hostages and 15 militants.

One American, from Texas, is among the dead, and the militants offered to trade two other American hostages for two terrorists behind bars in the U.S., an offer firmly rejected by Washington. At least one Briton, a Frenchman and Algerians have also died in the standoff. Escaped Algerian workers describe seeing people of many nationalities, including Japanese, shot down.

French Defense Minister Jean-Yves Le Drian said Saturday that there are believed to be no more French hostages in the gas complex. He said the Frenchman killed, Yann Desjeux, was a former member of the French Special Forces and part of the security team. The remaining three French nationals who were at the plant are now free, the Foreign Ministry said.

Britain's Foreign Secretary William Hague confirmed that as of Saturday, there were "fewer than 10" British nationals still at risk or unaccounted for and "the majority of" Britons at the plant were now safe, he said.

Statoil CEO Helge Lund said Saturday that there were only six Norwegians unaccounted for, from the 17 at the plant at the time of the attack.

Romanian Prime Minister Victor Ponta said Saturday one Romanian hostage was killed in the course of the siege, while four escaped unharmed.

The attack by the Mali-based Masked Brigade had been in the works for two months, a member of the brigade told the online Mauritanian news outlet. He said militants targeted Algeria because they expected the country to support the international effort to root out extremists in neighboring Mali and it was carried out by a special commando unit, "Those Who Signed in Blood," tasked with attacking nations supporting intervention in Mali.

The kidnappers focused on the foreign workers, largely leaving alone the hundreds of Algerian workers who were briefly held hostage before being released or escaping.

Several of them arrived haggard-looking on a late-night flight into Algiers on Friday and described how the militants stormed the living quarters and immediately separated out the foreigners.

Mohamed, a 37-year-old nurse who like the others wouldn't allow his last names to be used for fear of trouble for himself or his family, said at least five people were shot to death, their bodies still in front of the infirmary when he left Thursday night.

Chabane, who worked in food services, said he bolted out the window and was hiding when he heard the militants speaking among themselves with Libyan, Egyptian and Tunisian accents. At one point, he said, they caught a Briton.

"They threatened him until he called out in English to his friends, telling them, 'Come out, come out. They're not going to kill you. They're looking for the Americans,'" Chabane said.

"A few minutes later, they blew him away."

_____

Paul Schemm reported from Rabat, Morocco. Associated Press writers Aomar Ouali and Karim Kebir in Algiers; Oliver Teves in Manila, Philippines; Elaine Ganley in Paris; Sylvia Hui in London, and Jan M. Olsen in Copenhagen contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-01-19-Algeria-Kidnapping/id-600b00f013514dd0b9274998481bef90

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Friday, January 18, 2013

Business Roundtable Wants to Increase Medicare and Social ...

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In roughly a month Washington?s focus will again turn to attempts to get a ?grand bargain? on deficit reduction when the sequestration cuts are set to go into effect, so the Business Roundtable is already laying down their goals. Their proposal for Social Security and Medicare reform including adopting the chained-CPI and increasing the eligibility age for both programs to 70. There are trying to push the envelope on the issue of Medicare age beyond what has even been discussed so far. From the Business Roundtable:

Increase Retirement Age: The Social Security retirement age should be raised from age 67 to age 70. The unique needs of individuals in in physically demanding occupations should be accommodated and the Social Security Disability Insurance Program should be modernized. [...]

Protect Medicare for Those Approaching Retirement: Medicare?s age of eligibility should be moved to age 70. However, this will not affect those age 55 or older today.

Raising the Medicare age is an unique terrible policy idea. It doesn?t save the federal government much money and by forcing older people into the less cost effective private insurance, it increases overall health care spending. It increases spending for almost everyone including seniors, everyone buying individual insurance, and state Medicaid programs.

Basically the only group of people who would really benefit from this change would be individuals in the health care industry who would see their revenues increase significantly as a result. People like the CEO?s of Aetna, Unitedhealth, Pfizer and Merck who all happen to be members of the Business Roundtable.

Photo by Jos? Goul?o under Creative Commons license

Source: http://fdlaction.firedoglake.com/2013/01/17/business-roundtable-wants-to-increase-medicare-and-social-security-age-to-70/

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Scientists shed light on the 'dark matter' of DNA

Jan. 17, 2013 ? In each cell, thousands of regulatory regions control which genes are active at any time. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have developed a method that reliably detects these regions and measures their activity.

Information on the new technology was just published online in the journal Science.

Genome sequences store the information about an organism's development in the DNA's four-letter alphabet. Genes carry the instruction for proteins, which are the building blocks of our bodies. However, genes make up only a minority of the entire genome sequence -- roughly two percent in humans. The remainder was once dismissed as "junk," mostly because its function remained elusive. "Dark matter" might be more appropriate, but gradually light is being shed on this part of the genome, too.

Far from being useless, the non-coding part of DNA contains so-called regulatory regions or enhancers that determine when and where each gene is expressed. This regulation ensures that each gene is only active in appropriate cell-types and tissues, e.g. hemoglobin in red blood cell precursors, digestive enzymes in the stomach, or ion channels in neurons. If gene regulation fails, cells express the wrong genes and acquire inappropriate functions such as the ability to divide and proliferate, leading to diseases such as cancer.

Despite the importance of gene regulatory regions, scientists have been limited in their ability to study them on a genome-wide scale. Their identification relied on indirect means, which were error prone and required tedious experiments for validating and quantifying enhancer activities..

Alexander Stark and his team at the IMP in Vienna now closed this gap with the development of a new technology called STARR-seq (self-transcribing active regulatory region sequencing), published online by Science this week. STARR-seq allows the direct identification of DNA sequences that function as enhancers and simultaneously measures their activity quantitatively in entire genomes.

Applying their technology to Drosophila cells, the IMP-scientists surprisingly find that the strongest enhancers reside in both regulatory genes that determine the respective cell-types as well as in broadly active "housekeeping" genes that are required for basic cell survival in most or all cells. In addition, they find several enhancers for each active gene, which might provide redundancy to ensure robustness of gene regulation.

The new method combines advanced sequencing technology and highly specialized know-how in bio-computing. It is a powerful tool which, according to Alexander Stark, will prove immensely valuable in the future. "STARR-seq is like a magic microscope that lets us zoom in on the regulatory regions of DNA. It will be crucial to study gene regulation and how it is encoded in the genome -- both during normal development and when it goes wrong in disease."

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Story Source:

The above story is reprinted from materials provided by Research Institute of Molecular Pathology, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Arnold Cosmas D. Arnold, Daniel Gerlach, Christoph Stelzer, ?ukasz M. Bory?, Martina Rath, Alexander Stark. Genome-Wide Quantitative Enhancer Activity Maps Revealing Complex cis-Regulation of Transcription. Science, January 17, 2013 DOI: 10.1126/science.1232542

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/U7JAnX1gEnc/130117142432.htm

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